Optimized aperture selection imaging computed tomography system and method

ABSTRACT

The invention provides a method and imaging system for operating imaging computed tomography using a radiation source and a plurality of detectors to generate an image of an object. The method includes: defining a desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the radiation source, to generate said desired image quality or characteristics. Then, the radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can comprise at least one of desired levels of contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR), and may provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.

FIELD

This invention relates generally to the field of computed tomography (CT) and more particularly to an optimized aperture selection imaging CT (OASCT) system and method utilizing compensating filters to modulate the fluence pattern applied during image acquisition for specific distributions of dose and image noise.

BACKGROUND

The following paragraphs are not an admission that anything discussed in them is prior art or part of the knowledge of persons skilled in the art.

Current imaging practice attempts to acquire high image quality throughout a scanned volume, though some focus is now being directed at more patient specific methods of imaging. It is recognized that many imaging tasks only require elevated image quality in smaller volumes while low image quality would be sufficient throughout the remainder of the imaged volume. The development of techniques to perform region of interest (ROI) imaging (see R. Chityala, K. R. Hoffmann, S. Rudin, and D. R. Bednarek, “Region of interest (ROI) computed tomography (CT): Comparison with full field of view (FFOV) and truncated CT for a human head phantom,” Proc. SPIE Physics of Medical Imaging 5745, 583-590 (2005) and C. J. Moore, T. E. Marchant, and A. M. Amer, “Cone beam CT with zonal filters for simultaneous dose reduction, improved target contrast and automated set-up in radiotherapy,” Phys Med Biol 51, 2191-2204 (2006)) are a step towards acquiring images that provide varying image quality through the reconstructed volume. However, there remains a need for further improvements to be made by having the ability to optimally modulate the x-ray fluence patterns applied during imaging in a more patient specific fashion.

Many technologies have been developed for the purpose of improving external beam radiation therapy by imaging patients in the treatment position. These systems, which include CT imagers placed on rails in the treatment room (see K. Kuriyama, H. Onishi, N. Sano, et al. “A new irradiation unit constructed of self-moving gantry-CT and linac,” Int J Radiat Oncol Biol Phys 55, 428-35 (2003)), Tomotherapy (see T. R. Mackie, T. Holmes, S. Swerdloff, et al. “Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy.” Med Phys 20, 1709-19 (1993)), and imaging CT systems mounted on the gantries of conventional linear accelerators have the potential to improve radiation therapy targeting. One example of a CT imaging system is cone-beam CT (see D. A. Jaffray, J. H. Siewerdsen, J. W. Wong, and A. A. Martinez, “Flat-panel cone-beam computed tomography for image-guided radiation therapy,” Int J Radiat Oncol Biol Phys 53, 1337-1349 (2002)) and another example is scanning-beam CT (see E. G. Solomon, B. P. Wilfley, M. S. Van Lysel, A. W. Joseph, and J. A. Heanue, “Scanning-beam digital x-ray (SBDX) system for cardiac angiography,” in Medical Imaging 1999: Physics of Medical Imaging (SPIE, New York, 1999), Vol. 3659, pp. 246-257; T. G. Schmidt, J Star-Lack, N. R. Bennett, S. R. Mazin, E. G. Solomon, R Fahrig, N. J, Pelc, “A prototype table-top inverse-geometry volumetric CT system.” Medical Physics, June 2006 33(6), pp. 1867-78). With this improvement comes the possibility of reducing planned treatment volumes (PTVs), increasing the sparing of normal tissues and increasing the dose to tumors. The contents of all these publications are hereby incorporated by reference.

Also, a large quantity of work has been accomplished to improve the ability of systems designed for image guided radiation therapy to improve patient outcome. For the case of cone-beam CT, there is a large interest in developing flat-panel detectors with improved performance (dynamic range, spatial resolution) and removing the effects of scattered x-rays reaching the detector. It has now been shown that implementing compensating filters into imaging CT systems has the potential to play a large role in reducing scatter that reaches the detector, as well as scatter within the patient delivering unnecessary patient dose.

Accordingly, there is a need for an imaging system to optimize image quality in the most clinically relevant regions of an image, while reducing dose to the patient by reducing the fluence intensity outside defined regions of interests.

INTRODUCTION

The following introduction is intended to introduce the reader to this specification but not to define any invention. One or more inventions may reside in a combination or sub-combination of the apparatus elements or method steps described below or in other parts of this document. The inventor does not waive or disclaim his rights to any invention or inventions disclosed in this specification merely by not describing such other invention or inventions in the claims.

In accordance with a first aspect of the present invention, there is provided a method for operating imaging computed tomography using a radiation source and a plurality of detectors to generate an image of an object, the method comprising the steps of:

(a) defining desired image characteristics;

(b) performing calculations to determine the pattern of fluence to be applied by the radiation source, to generate said desired image characteristics; and

(c) modulating the radiation source to generate said pattern of fluence between the beam source and the object to be imaged.

A second embodiment of the present invention provides an imaging system, the system comprising:

(a) a radiation source for directing a beam at an object to be imaged;

(b) a modulator placed between said beam source and the object to be imaged; and

(c) a computer for performing calculations based on the desired distribution of image quality to determine the pattern of fluence to be applied by said temporal modulator.

The present invention can be applied to any suitable object. It is expected that it will be commonly used to examine a human or animal body.

BRIEF DESCRIPTION OF THE DRAWINGS

For a better understanding of the present invention, and to show more clearly how it may be carried into effect, reference will now be made, by way of example, to the accompanying drawings which show some examples of the present invention, and in which:

FIG. 1 is a block diagram of an example implementation of the imaging CT system of the present invention;

FIG. 2 is an illustrative block diagram of the imaging geometry being imaged by the imaging CT system of FIG. 1; and

FIG. 3 is a flow chart illustrating the general process steps for optimal modulation determination;

FIG. 4 shows a mathematical phantom used to model the present invention;

FIGS. 5 a and 5 b show two desired SNR images;

FIG. 6 shows a graph of a cost function;

FIG. 7 shows a modulation function as a function of gantry angle and position;

FIGS. 8 a, 8 b, 8 c and 8 d show, respectively, theoretical SNR with no modulation, SNR after optimization with uniform W_(SNR), image acquired with no modulation, and image acquired using modulation pattern;

FIGS. 9 a and 9 b show, respectively, the SNR distribution and the image acquired with W_(SNR) tripled in regions of higher SNR;

FIGS. 9 c and 9 b show, respectively, the SNR distribution and the image acquired with W_(SNR) tripled in regions of higher SNR, using the SNR from FIG. 5 b;

FIG. 10 a shows a first embodiment of temporal compensation scheme, comprising a louvre compensator; and

FIG. 10 b shows the louvre compensation of FIG. 10 a in a partial open position;

FIG. 10 c shows the louvre compensation of FIGS. 10 a, b in use;

FIG. 11 a shows an example of another temporal compensation scheme, comprising a multi-leaf compensator; and

FIG. 11 b shoes the multi-leaf compensation of FIG. 11 a in use.

It will be appreciated that for simplicity and clarity of illustration, elements shown in the figures have not necessarily been drawn to scale. For example, the dimensions of some of the elements may be exaggerated relative to other elements for clarity. Further, where considered appropriate, reference numerals may be repeated among the figures to indicate corresponding or analogous elements.

DETAILED DESCRIPTION

Various apparatuses or methods will be described below to provide an example of an embodiment of each claimed invention. No embodiment described below limits any claimed invention and any claimed invention may cover apparatuses or methods that are not described below. The claimed inventions are not limited to apparatuses or methods having all of the features of any one apparatus or method described below or to features common to multiple or all of the apparatuses described below. It is possible that an apparatus or method described below is not an embodiment of any claimed invention. The applicants, inventors and owners reserve all rights in any invention disclosed in an apparatus or method described below that is not claimed in this document and do not abandon, disclaim or dedicate to the public any such invention by its disclosure in this document.

The present invention has the potential to decrease dose to patients by concentrating image quality on desired regions of interest (ROIs) or distributions of image quality. An iterative optimization process is utilized to design patterns of modulation to be applied during imaging to acquire images as near as possible to those desired. This optimizing process can account for numerous parameters of the imaging CT system, including the efficiency of the detector, the presence of x-ray scatter reaching the detector, and the constraints of the modulator used to form the intensity modulated fluence patterns.

Reference is first made to FIG. 1, which illustrates an imaging CT system 10 made in accordance with a preferred embodiment of the present invention. Imaging CT system 10 can be any method of CT imaging, such as a cone-beam CT system or a scanning-beam CT system. It can also be an inverse-geometry volumetric system, as disclosed in the paper by T. G. Schmidt et al. noted above. Note that configurations of the present invention are not limited to x-ray sources or x-ray radiation and are applicable to other imaging systems, although the configuration of CT imaging systems, utilize an x-ray source and x-ray radiation.

Imaging CT system 10 comprises of an x-ray source 12, a modulator 14, an object to be imaged 16, an array of detectors 18, and a computer 20. Both x-ray source 12 and array of detectors 18 are placed on a rotational gantry (not shown) and are able to continuously rotate around the object to be imaged 16, so that the angle at which x-ray beam 13 intersects with the object to be imaged 16 constantly changes. The Modulator 14 is a device placed between the x-ray source 12 and the object to be imaged 16 for effecting the desired fluence pattern as determined by computer 20. Detector array 18 is formed by a plurality of detector rows (not shown) including a plurality of detector elements (not shown) which together sense the radiation that passes through the object to be imaged 16. In operation, x-ray source 12 emits x-ray beams 13 through modulator 14 towards the object to be imaged 16 so that the array of detectors 18 can detect the x-ray fluence passing through the object to be imaged 16.

The resulting signals at the array of detectors 18 are then sampled by a data measurement system (not shown) to build up a projection, and subsequently a reconstructed volume. Note that the optimized aperture selection CT system and method can be implemented for any number of imaging geometries, source-detector trajectories, or reconstruction algorithms, such as cone-beam CT or scanning-beam CT.

Computer 20 is the computational engine of imaging CT system 10 which generates the operational parameters of modulator 14 to control the pattern of fluence to be applied during image acquisition based on a desired distribution of contrast-to-noise-ratio (CNR) (as will be discussed further below). Computer 20 makes use of either previously acquired patient images 22 to define regions of interest (ROIs) or a library of population models 24 to define a distribution of desired image quality.

Referring now to FIGS. 2 and 3, the general process steps 100 for determining optimized fluence patterns through modulation will be described for the imaging geometry 50 shown. Both the theory behind the design of imaging CT system 10 and its practical applications will be described in detail below.

At step 102, the process begins with an estimate of the object to be imaged 16 provided to computer 20. Object to be imaged 16 is described by attenuation function μ({right arrow over (r)}) 52 where {right arrow over (r)} is the position of the voxels in the volume. Projection images of the object 52 are acquired by first directing a two-dimensional x-ray beam I^(o) (u,v) 54 towards the object at each angle θ_(i) 58 to determine the detected x-ray fluence I_(θ) _(i) (u,v) 56 after passage through the object. The variables u and v represent the pixel matrix of the x-ray detector in use. In this work v=v(z) and u=u(x,y) where x, y, and z are the dimensions of the object being imaged The x-y plane, or imaging plane, is the plane where the x-ray beam 54 projected by x-ray source is collimated to lie. The projections, without any modulation applied to the x-ray beam, are given by the following:

P _(θ) _(i) (u,v)=−1n(I _(θ) _(i) /I ^(o))  [/1]

In the present system and method, a modulation function m_(θ) _(i) (u,v) is introduced to provide modulated fluence patterns during imaging, and is effected in imaging CT system 10 through modulator 14. The modulation function, with values in the interval [0,1], describes the percentage of the incident two-dimensional x-ray beam 54 to be directed at the scanned object for each pixel (u,v) and each angle θ_(i) 58. Where the modulation factor is 1, this would be equivalent to imaging without any modulating filter placed in the beam. Introduction of this modulation factor causes the x-ray fluence incident on the scanned object 54 to be m_(θ) _(i) (u,v)I^(o)(u,v), and the detected fluence through the object 56 to be m_(θ) _(i) (u,v)I_(θ) _(i) (u,v). From these values the modulated projection images can be determined as:

P _(θ) _(i) ^(m)(u,v)=1n(m _(θ) _(i) (u,v)I ^(o)(u,v))−1n(m _(θ) _(i) (u,v)I _(θ) _(i) (u,v))=−1n(I _(θ) _(i) /I ^(o))  [2]

and it is seen that imaging with modulated fluence patterns has no effect on the expected value of the projections for this idealized case.

The effect of the modulation is only seen when the noise in the projections is investigated. Assuming that the x-ray fluence is Poisson distributed, then the variance of the x-ray fluence through the object 52 will be given by the expected value of the fluence, Ī_(θ) _(i) (u,v) For the modulated fluence patterns the variance will be m_(θ) _(i) (u,v) Ī_(θ) _(i) (u,v). This leads to variances in the projections of

$\begin{matrix} {{{var}\left\{ {P_{\theta_{i}}\left( {u,v} \right)} \right\}} = \frac{1}{{\overset{\_}{I}}_{\theta_{i}}\left( {u,v} \right)}} & \lbrack 3\rbrack \end{matrix}$

for the unmodulated case, and

$\begin{matrix} {{{var}\left\{ {P_{\theta_{i}}^{m}\left( {u,v} \right)} \right\}} = \frac{1}{{m_{\theta_{i}}\left( {u,v} \right)}{{\overset{\_}{I}}_{\theta_{i}}\left( {u,v} \right)}}} & \lbrack 4\rbrack \end{matrix}$

for the modulated fluence patterns. So, although the modulation function does not affect the expected value of the projections, it does affect the noise in the projections.

The projections can be used to form volumetric reconstructions. For a parallel beam geometry with no scatter or energy dependence the reconstructed image can be found with the formula

$\begin{matrix} {{f\left( {x,y,z} \right)} = {\frac{\pi\tau}{M_{proj}}{\sum\limits_{i = 1}^{M_{proj}}{\sum\limits_{k}{{P_{\theta_{i}}^{m}\left( {u,v} \right)}{h\left( {{x\; \cos \; \theta_{i}} + {y\; \sin \; \theta_{i}} - {k\; \tau}} \right)}}}}}} & \lbrack 5\rbrack \end{matrix}$

where M_(proj) is the total number of projection images, τ is the sampling interval of the object, and h is the inverse Fourier transform of the filtering function. The filtering of the projection takes place in the u(x,y) dimension of the projections, and is performed for each value of v(z). The expected value of the reconstruction is not affected by the modulation function, but the variance of the reconstructed image depends on the variance of the projections, given by the formula:

$\begin{matrix} {{{var}\left\{ {f\left( {x,y,z} \right)} \right\}} = {\left( \frac{\pi \; \tau}{M_{proj}} \right)^{2}{\sum\limits_{i = 1}^{M_{proj}}{\sum\limits_{k}{\frac{1}{{m_{\theta_{i}}\left( {u,v} \right)}{{\overset{\_}{I}}_{\theta_{i}}\left( {u,v} \right)}}{h^{2}\left( {{x\; \cos \; \theta_{i}} + {y\; \sin \; \theta_{i}} - {k\; \tau}} \right)}}}}}} & \lbrack 6\rbrack \end{matrix}$

So it is evident that depending on the selection of the modulation function m_(θ) _(i) (u,v) there can be a variation in noise across a reconstructed volume. As such, the object of the present invention is then to determine the modulation function that is optimal for a desired imaging task.

At step (104), the desired distribution can be defined. Given some metric C({right arrow over (r)}) describing image characteristics (e.g. contrast-to-noise ratio (CNR) or signal-to-noise ratio (SNR) in a volumetric image, computer 20 determines a modulation function m_(θ) _(i) (u,v) which can be applied to x-ray intensities incident on the scanned object 52 to obtain an image which falls within a specified range from C({right arrow over (r)}). An example of an image characteristic is the contrast-to-noise ratio (CNR), where the CNR distribution in the body for CT is dependent upon both the constraints of the object 52 and the fluence pattern applied 54 in the generation of the CT image, namely CNR({right arrow over (r)})=f(μ({right arrow over (r)}), I_(θ) _(i) (u,v)). The CNR ({right arrow over (r)}) would be designed according to the object 52 and the anticipated location of the object 52 at the time of imaging.

The necessary modulation can be found by solving the inverse problem

m(u,v)I(u,v)=G ⁻¹ [C({right arrow over (r)})]  [7]

where G⁻¹ is an operator which relates the image metric C({right arrow over (r)}) to the applied radiation intensities. This will result in a reconstructed image {circumflex over (f)}({right arrow over (r)}) where

C ({right arrow over (r)})≦{circumflex over (f)}({right arrow over (r)})≦ C ({right arrow over (r)})  [8]

with C(r) and C({right arrow over (r)}) being the lower and upper bounds respectively desired of C({right arrow over (r)}) at each point {right arrow over (r)}. This accounts for the fact that the desired C({right arrow over (r)}) may not be obtainable with the possible modulation combinations. For example, if a matrix containing the desired image quality was 65×65 pixels, and 180 projections were desired, this would result in a modulation factor matrix of size 65×180 (a total of 11,7000 values to be optimized). However, it is noted that one could cut the amount of processing required by using the symmetry of the desired image quality patterns optimized for the number of angles required to determine the modulation factor, reducing the problem to only 5,850 values.

An upper bound on C({right arrow over (r)}) is necessary to limit the dose applied during image acquisition, while the lower bound is necessary if sufficient image quality is to be obtained. Variable image quality can be defined in different regions of the image depending on the imaging task.

Careful characterization of the imaging CT system 10 is necessary to find the relationship between m_(θ) _(i) (u,v) and C({right arrow over (r)}). In order to plan the fluence patterns that will lead to the desired image, it is necessary to take various quantities, that are also modulated by m_(θ) _(i) (u,v), into account such as: the dose in the scanned object where D({right arrow over (r)})=D(μ({right arrow over (r)}),I^(o)(u,v),m_(θ) _(i) (u,v)), the scattered radiation inherent to imaging CT systems I^(s)(μ({right arrow over (r)}),I^(o)(u,v),m_(θ) _(i) (u,v)), and the exposure dependent detective quantum efficiency of the detector DQE(ν,μ({right arrow over (r)}),D/proj,I^(o)(u,v),m_(θ) _(i) (u,v)). The computational engine of computer 20 comprises a model for dependence of CNR({right arrow over (r)}) and D({right arrow over (r)}) on I_(θ) _(i) (u,v), including the above mentioned quantities.

It is not expected that it will be possible to determine an analytical solution to the inverse problem when taking account of the numerous dependencies. The constraints of the problem will be satisfied by computer 20 determining a numerical solution to the problem at step (106).

An iterative solution could have a form

min{∥C({right arrow over (r)})−C_(i)({right arrow over (r)})∥}  [9]

where with each step i the image metric C_(i)({right arrow over (r)}) is calculated from the given properties of the imaging CT system 10 and compared to the desired quantity C({right arrow over (r)}). Changes to the fluence modulating function m_(θ) _(i) (u,v) can be applied so that C_(i)({right arrow over (r)}) approaches C({right arrow over (r)}). For every iterative step this process will require determining the value of C_(i)({right arrow over (r)}) given appropriate inputs. The determination of C_(i)({right arrow over (r)}) can be accomplished by applying pre-determined look-up tables which contain information involved in the relationship between m_(θ) _(i) (u,v) and C({right arrow over (r)}). With more flexibility available for the choice of m_(θ) _(i) (u,v) it becomes necessary to create more complicated look up tables.

Additionally it is possible to optimize multiple properties of the imaging CT system 10. For example, a modulation function could be found to achieve both an optimal image quality, ∥(C({right arrow over (r)})−C_(i)({right arrow over (r)})∥, and an optimal patient dose, ∥D({right arrow over (r)})−D_(i)({right arrow over (r)})∥, and an appropriate weighting could combine the two to determine the optimal modulation to apply to the fluence patterns, resulting in an iterative solution of the form

min{∥C({right arrow over (r)})−C_(i)({right arrow over (r)})∥+w∥D({right arrow over (r)})−D_(i)({right arrow over (r)})∥}  [10]

Another possible addition to this optimization would be to not only weight the relative importance of image quality and dose across the entire image, but to also weight the importance of dose and image quality in individual voxels. This would require a matrix of weights for image quality, W_(C)({right arrow over (r)}), and for dose, W_(D)({right arrow over (r)}), giving a final form for the iterative solution of

min{∥W_(C)({right arrow over (r)})(C({right arrow over (r)})−C_(i)({right arrow over (r)}))∥+w∥W_(D)({right arrow over (r)})(D({right arrow over (r)})−D_(i)({right arrow over (r)}))∥}  [11]

Although the parameters of x-ray scatter reaching the detector and the energy dependence of the x-rays used for imaging have been let out of the formulation discussed above, it should be apparent to one skilled in the art on how to modify the above formulas to account for these parameters.

In an alternate embodiment, computer 20 of imaging CT system 10 could potentially use a small library of general modulation factors that are designed for certain anatomical regions. This would shorten the optimization process 100 as described above when performed for specific patients.

Finally, at step (108), once the proper modulation function is determined by computer 20 using the method described above, modulation can be applied during image acquisition. There are various possibilities for the construction of the modulator 14. A main consideration is whether to use a modulator 14 that operates with spatial modulation or temporal modulation.

A modulator 14 that spatially modulates would consist of a shaped material that uses differing thicknesses of the material to absorb differing percentages of the primary x-rays. One example of a simple spatially modulating filter is a Cu Compensator, where the modulator has a shape that is thicker for outer detector rows and thinner for inner detector rows. As a result of this shape the x-rays corresponding to the outer detector rows undergo greater filtering than the x-rays corresponding to the inner detector rows (see U.S. Pat. No. 6,647,095, Jiang Hsieh). For imaging CT system 10 the modulator 14 would ideally be able to have a different optimized shape for each angle that a projection image is acquired at. One of the potentially problematic aspects of the spatially modulated approach is the energy dependent absorption of the x-rays by the modulator 14. As has already been shown (see S. A. Graham, D. J. Moseley, J. H. Siewerdsen, and D. A. Jaffray, “Compensators for dose and scatter management in cone-beam CT” Med Phys (submitted)) spectral hardening from shaped filters placed in the beam can cause artifacts in reconstructed volumetric images. If this problem cannot be addressed it may be necessary to investigate alternate approaches.

Temporal modulation is a possibility for avoiding problems associated with the energy dependent properties of the x-rays used for imaging. Rather than consisting of a material that partially absorbs incident x-rays a temporal modulator would be constructed of a material that absorbs most, if not all, of the incident photons. The modulation would be provided by having the modulator 14 block the x-rays for different amounts of time while moving across the projection image. FIG. 10 illustrates an embodiment of a temporal modulating filter, called a louvre compensator, where the material contains louvres that can be independently turned to create small field sizes during imaging. A combination of many of these small fields would provide the intensity-modulated pattern. FIG. 11 illustrates another embodiment, namely a multi-leaf compensator, where the material is made of small individual ‘leaves’ that slide across the field-of-view to create intensity modulated patterns. This approach would be similar to dynamic MLC IMRT (see P. Keall, Q. Wu, Y. Wu, and J. O. Kim, “Dynamic MLC IMRT,” in Intensity-modulated radiation therapy: The state of the art. Edited by J. R. Palta and T. R. Mackie. Medical Physics Publishing, Madison, 2003), the contents of which are hereby incorporated by reference. It should be noted that both compensator examples could be constructed with any number of louvres or leaves depending on how coarse or fine a modulation pattern is desired. Although temporal modulation removes the complication of the energy dependent x-ray spectrum, there are other possible obstacles to be addressed. One possible issue is that the edges of the leaves in the modulator 14 may cause artifacts in the images that cannot be easily removed. There may also be difficulties in constructing a modulator 14 capable of moving the leaves with speeds high enough to modulate the fluence pattern during a projection, which takes place in a time on the order of 10 ms.

III. Demonstration of Optimized Aperture Selection CT

A demonstration of the ability to optimize fluence patterns to arrive at a desired image was performed in Matlab™. Optimized fluence patterns were determined for a circular mathematical phantom containing three simulated ‘nodules’ 30 of slightly different attenuation, in a body 32, as shown in FIG. 4. The optimization for determining the optimized fluence patterns was performed on a mathematical phantom without any simulation of surrounding soft tissue structure. This was done because when using this technique on patients we would not know the exact location of all soft tissue structures. It was decided that the optimization should be performed on a uniform object to avoid the changes in SNR that would be introduced by the change in attenuation. If the imaged area was to include regions with large variation in attenuation (i.e. bone or lung tissue) it is expected that these tissues would need to be included in the optimization.

The optimization routines available in Matlab were not able to manage the large number of variables to be optimized, requiring an alternative method to be used. A simple simulated annealing code was written to find modulated fluence patterns that provided low values of the cost function being minimized. The simulated annealing algorithm proceeds towards an optimized solution by randomly selecting a new solution that is near the current solution, and then comparing the two. If the cost function that is being minimized decreases with the new solution it is accepted and the algorithm can proceed to the next iteration. If, on the other hand, the cost function increases, the new solution is accepted with a probability:

$\begin{matrix} {\Pr = {\exp \left( {- \frac{\Delta \; {CF}}{T}} \right)}} & \lbrack 12\rbrack \end{matrix}$

where ΔCF is the change in the cost function, and T is the current unitless “temperature” of the system (if the cost function were a measure of the energy of the system, then unitless temperature would be replaced by kBT where kB is the Boltzmann constant and T is a temperature measured, for example, in Kelvin). For the simulations shown here a geometric temperature decrease was used so that the unitless temperature for an iteration i+1 was given by:

T _(i+1) =αT _(i)  [13]

where Ti is the temperature in the previous iteration, and α is a constant with a value between 0 and 1. This constant was chosen to be 0.9998 to provide very slow cooling of the system.

Two different examples of the desired SNR, SNR_(D) are shown in FIGS. 5 a and 5 b. Both figures have SNR values of 30, 15, 5, and 0. The SNR value of 30 is represented by the lightest nodule 40 a in the phantom and the SNR value of 0 is represented by the dark area 46 a outside the phantom. In FIG. 5 a the SNR was designed to be 15 at the skinline 42 a and 5 throughout the rest of the phantom, indicated at 44 a. While in FIG. 5 b most of the phantom is defined as an SNR 15, indicated at 42 b, with a region at the bottom of the phantom designed to be a region where less dose is desired, indicated at 44 b. Both desired SNR images were used to determine optimal fluence patterns for the mathematical phantom. The matrices containing the desired SNR values were 65×65 pixels, and 180 projections were desired of the phantom, resulting in a modulation factor matrix of size 65×180 (a total of 11,700 values to be optimized). Using the symmetry of the SNR patterns optimized for the number of angles required to optimize the modulation factor over could be cut in half, reducing the problem to 5,850 values to be optimized. The initial value of the modulation factor was chosen to be one everywhere, which would be equivalent to imaging without any modulating filter placed in the beam. The cost function for iteration i was described by

$\begin{matrix} {{CF}_{i} = {\frac{\left( {\sum\limits_{x,y}\left( {W_{SNR}\left( {{SNR}_{i} - {SNR}_{D}} \right)} \right)^{2}} \right)}{\left( {\sum\limits_{x,y}\left( {W_{SNR}\left( {{SNR}_{o} - {SNR}_{D}} \right)} \right)^{2}} \right)} + {w\frac{\left( D_{i} \right)}{\left( D_{o} \right)}}}} & \lbrack 14\rbrack \end{matrix}$

The matrix W_(SNR) weighted the SNR difference in each pixel differently before the sum in each pixel was calculated. Although the dose across the image could be similarly weighted, in this case only the total dose absorbed by the phantom was used. The dose and totaled SNR difference were normalized by their initial values to facilitate comparison between the values. The value of w to weight the sum of the two normalized values was set at one to provide equal weighting between reducing dose and providing the desired SNR. This also results in a cost function with an initial value of two, as shown in FIG. 6.

As illustrated in FIG. 6 the cost functions tended to have an initial sharp decrease followed by a slow decrease. The cost function, which began with a value of two, was reduced to a value of 0.5 in approximately 20 iterations. This is because the initial modulation provided the highest dose possible. Beginning the optimization with a solution that is nearer to an optimized solution removes the sharp decrease at the beginning of the optimization process. Implementing OASCT could potentially use a small library of general modulation factors that are designed for certain anatomical regions. This would shorten the optimization process when performed for specific patients.

For the SNR distribution shown in FIG. 5 a the optimization process determined a value for m_(θ) _(i) (u,v) (FIG. 7) using equal weighting on all SNR values (W_(SNR) equal to one). The right hand portion of FIG. 7 indicates a scale indicative of the value of the modulation function, m_(θ) _(i) (u,v) in the range [0,1]. The main portion of FIG. 7 shows the variation of the modulation function as a function of gantry angle, shown on the horizontal axis, and positioned across the image, shown along the vertical axis. As shown in FIG. 7, the value of m_(θ) _(i) (u,v) corresponding to where low SNR is desired had a value of approximately 0.04. For other positions, there is a band of higher value modulation function, which shifts following a sine waveform as shown in FIG. 7. Thus, at either side of FIG. 7, for gantry angles of 0 degrees and 180 degrees, this higher value modulation function is found at approximately kτ=0. It shifts downwards towards kτ=approx. 10, for the gantry angle 90 degrees. This is so that the desired SNR values will be achieved as closely as possible.

Applying this modulation gave images with distinct patterns of SNR (FIGS. 8 a, 8 b, 8 c, 8 d). FIG. 8 a illustrates the theoretical SNR in an unmodulated case. FIG. 8 b illustrates the SNR after the optimization process with uniform W_(SNR). FIG. 8 c illustrates the image acquired with no modulation and FIG. 8 d illustrates the image acquired using the modulated pattern. The theoretical SNR shown is based on the evaluation of equations 5 and 6. The desired SNR was not achieved, likely because what was defined as the desired SNR was impossible to achieve given the constraints of the system. FIG. 8 b shows SNR values of approximately 19, 8.3, and 6.5 at the locations where the SNR was defined to be 30, 15, and 5. FIG. 8 a, with no modulation applied, had an SNR of approximately 30 across the image. The relative doses in the unmodulated and modulated cases were 1 and 0.15 respectively. The CNR of the nodules was 6.6±1.2 in the unmodulated case, and decreased to 3.2±0.9 when modulation was applied. The cost function was decreased from 2 to 0.082.

If the weighting W_(SNR), is changed on the SNR a different m_(θ) _(i) (u,v) will be found. Performing the same optimization, but changing W_(SNR) to be 3 where the SNR is desired to be 30, and keeping it as 1 everywhere else, provides a optimization with higher dose, and less noise where we desire high SNR. FIG. 9 a shows the SNR distribution when W_(SNR) is tripled and in this case the relative dose is increased to 0.21, the SNR (where it had a desired value of 30) was approximately 24, and the CNR of the nodules was 3.9±0.7. FIG. 9 b shows the image acquired when the W_(SNR) is tripled in the region of higher SNR.

For the optimization using the SNR from FIG. 5 b, W_(SNR) was set at 3 for the areas where SNR was desired to be 30 and 5. W_(SNR) was one where SNR was desired to be 15. FIG. 9 c shows the SNR distribution when W_(SNR) is tripled and for this case the SNR achieved was approximately 21, 7.8, and 5.9 for the regions that were desired to be 30, 15, and 5. The relative dose was 0.18 and the CNR of the nodules was 3.7±0.7. FIG. 9 d shows the image acquired when the W_(SNR) is tripled for the desired SNR shown in FIG. 5 b.

OASCT has the potential to greatly decrease dose to patients by concentrating image quality on desired regions of interest (ROIs). It will allow the prescription of desired image quality and dose throughout a volume, and an iterative optimization process will design patterns of modulation to be applied during imaging to acquire images as near as possible to those desired. This optimization process can account for numerous parameters of the imaging system, including the efficiency of the detector, the presence of x-ray scatter reaching the detector, and the constraints of the modulator used to form the intensity modulated fluence patterns. As mentioned above, there are various possibilities for constructing the modulator, using either a spatial or temporal compensating filter. For OASCT a spatial modulator would ideally be able to have a different optimized shape for each angle that a projection image is acquired at.

The simulation detailed above demonstrates the potential of this method, but more advanced work may be needed to be performed to determine how a real system may respond to the application of OASCT. The use of Monte Carlo methods (see G. Jarry, S. A. Graham, D. J. Moseley, et al. “Characterization of scattered radiation in kV CBCT images using Monte Carlo simulations,” Med Phys. (submitted)) is a possibility for investigating OASCT. This would allow realistic modeling of OASCT, with the additional benefit of being able to choose which properties are included so that they may be studied individually (as opposed to experimental imaging CT measurements where it may be difficult to separate the causes and effects of different properties).

The mathematical formulation helps to demonstrate how modulation can be used to alter the noise in projections and reconstructed volumes. However, the formulas used are for parallel beam geometry, but the OASCT imaging system can be implemented for any number of imaging geometries, source-detector trajectories, or reconstruction algorithms. Also left out of the formulation are quantities such as the x-ray scatter reaching the detector and the energy dependence of the x-rays used for imaging. Although these omissions may affect the results in equations 5 and 6 it is expected that modulated fluence patterns still have the ability to provide the desired optimized images. The optimization process to determine the modulated fluence patterns will be a mathematical optimization rather than an exact inversion so that equations similar to 5 and 6 are not necessary to implement OASCT.

Reference will now be made to FIG. 10 and details of a louvre compensator. This compensator comprises two sets of louvres 110, 112 extending perpendicularly to one another and overlapping so that rotation of individual louvres may be used to select a desired opening. The louvres are formed from a material that absorbs substantially all the x-rays incident on them, so that the effective x-ray beam is the opening in the louvre compensator.

FIG. 10 b shows one simple opening scheme where one louvre 110 a in the first set of louvres and another louvre 110 b in the second set are both rotated through 90 degrees so as, in effect to provide two open slots running perpendicularly to one another. The individual louvres 110 a, 110 b will be located in the middle of these slots but their dimensions are such that they will have no significant effect on the x-ray beam as it passes through each slot thus formed.

As indicated in FIG. 10 c, an x-ray beam originates as a cone-beam from source 114 and is instant on the louvre compensator 110, 112. Due to the open configurations of the individual louvres 110 a, 112 a, an approximately square aperture is provided, that permits an x-ray beam 116 of square, conical shape to extend towards and through a body indicated schematically at 118. The beam passes through the body and is detected at a detector.

Referring to FIG. 11, this shows an alternative compensator scheme, with a compensator indicated schematically at 130. Here, the compensator 130 includes a plurality of individual pairs of elements indicated for one pair 132 a, 132 b. These elements 132 a, 132 b are movable in and out from a central plane as indicated by the arrows 136, so as to define the shape and area of an aperture 134.

Referring to FIG. 11 b, with a selected aperture 134 set for the compensator 130, an x-ray source 138 is then arranged, to pass a beam through the aperture 134. This generates a beam of the desired shape as indicated at 140. The shaped beam 140 then passes through a body indicated schematically at 142, to impinge on a detector 144.

It will be understood that, either instead of or as well as, the temporal modulators shown in FIGS. 10 and 11, one or more spatial moderators can be used. A spatial moderator will provide some fixed modulation, and may result in some beam hardening.

Accordingly, it is shown that it is possible to design an imaging CT system with gantry angle dependent compensation, capable of achieving desired image quality in defined ROIs and distributions.

While certain features of the invention have been illustrated and described herein, many modifications, substitutions, changes, and equivalents will now occur to those of ordinary skill in the art. It is, therefore, to be understood that the appended claims are intended to cover all such modifications and changes as fall within the true spirit of the invention. 

1. A method for operating imaging computed tomography using a radiation source and a plurality of detectors to generate an image of an object, the method comprising the steps of: a) defining desired image characteristics; b) performing calculations to determine the pattern of fluence to be applied by the radiation source, to generate said desired image characteristics; and c) modulating the radiation source to generate said pattern of fluence between the beam source and the object to be imaged.
 2. The method of claim 1, wherein said desired image characteristics comprise at least one of desired levels of contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR).
 3. The method of claim 2, wherein said desired image characteristics providing at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.
 4. The method of claim 1 wherein performing said calculations comprises solving an inverse problem using an iterative solution.
 5. The method of claim 4, wherein said calculations being performed include considering at least one of: i) The dependence of the image quality on primary fluence transiting through the object. ii) The dependence on scatter fluence to the detector. iii) The dependence upon scattered dose to the object and its dependence on φ(θ,u,v). iv) The exposure dependent DQE of the detector DQE(φ(θ,u,v)).
 6. The method of claim 3, including constraining the calculations by a dose distribution constraint.
 7. A method as claimed in claim 4 including defining a region of interest from a library of population modules or at least one previously acquired image of the object. [alternatively a pre-scan of the image can be conducted]
 8. The method of claim 7 comprising performing said calculations to determine the pattern of fluence by solving the inverse problem according to the equation: m(u,v)I(u,v)=G ⁻¹ [C({right arrow over (r)})]  [7] where C({right arrow over (r)}) is and image metric defining the desired image characteristic, I (u, v) represents the intensity of the radiation applied to the object from the source and m(u, v) represents the modulation of the radiation by the object, and where G⁻¹ is an operator which relates the image metric C({right arrow over (r)}) to the applied radiation intensities, and wherein the method further comprises iteratively solving the equation: min{∥C({right arrow over (r)})−C_(i)({right arrow over (r)})∥} where, for each step i, the image metric C_(i)({right arrow over (r)}) is calculated and compared to the desired quantity C({right arrow over (r)}).
 9. The method of claim 8, including lower and upper bounds on the image metric, whereby in the reconstructed image: C ({right arrow over (r)})≦{circumflex over (f)}({right arrow over (r)})≦ C ({right arrow over (r)})  [8] where C({right arrow over (r)}) and C({right arrow over (r)}) are lower and upper bounds respectively of the desired of C({right arrow over (r)}) at each point {right arrow over (r)}.
 10. The method of claim 9, including optimizing image characteristics and dose iteratively according to: min{∥C({right arrow over (r)})−C_(i)({right arrow over (r)})∥+w∥D({right arrow over (r)})−D_(i)({right arrow over (r)})∥} wherein ∥(C({right arrow over (r)})−C_(i)({right arrow over (r)})∥ represents optimal image quality, ∥D({right arrow over (r)})−D_(i)({right arrow over (r)})∥ represents optional patient dose, and w is weighting given to the dose.
 11. The method of claim 10, including providing different weighting to the image characteristics and the patient dose.
 12. The method of claim 11, including weighting at least one of the image quality and the patient dose across individual voxels according to: min{∥W_(C)({right arrow over (r)})(C({right arrow over (r)})−C_(i)({right arrow over (r)}))∥+w∥W_(D)({right arrow over (r)})(D({right arrow over (r)})−D_(i)({right arrow over (r)}))∥}
 13. The method of claim 1, including providing temporal modulation of the radiation source.
 14. The method of claim 1, including providing spatial modulation of the radiation source.
 15. The method of claim 1, including both spatial and temporal modulation of the radiation source.
 16. The method of claim 14 or 15, comprising providing a temporal modulator comprising a plurality of individual elements adapted to absorb radiation, and moving these elements to provide desired temporal modulation
 17. An imaging system, the system comprising: a) a radiation source for directing a beam at an object to be imaged; b) a modulator placed between said beam source and the object to be imaged; and c) a computer for performing calculations based on the desired distribution of image quality to determine the pattern of fluence to be applied by said temporal modulator.
 18. An imaging system as claimed in claim 17, wherein the modulator comprises at least one of a spatial modulator and a temporal modulator.
 19. An imaging system as claimed in claim 17, wherein the modulator comprises a plurality of individual elements, each being substantially impervious to the radiation and being movable between an open position and a closed position, whereby open positions of the individual elements define an aperture permitting passage of the beam from the radiation source.
 20. An imaging system as claimed in claim 19, wherein the compensator is configured as a louvre compensator comprising a first set of substantially parallel louvres extending in one direction and a second set of parallel louvres extending in another direction, whereby by selected positioning of at least one louvre of the first set in the open position and at least one louvre of the second set in the open position an aperture is defined for passage of the beam of radiation.
 21. An imaging system as claimed in claim 17, wherein the compensator comprises a plurality of pairs of elements, the elements in each pair being elongate and extending end to end, and the pairs of elements being arranged in a side by side abutting relationship, wherein, with all the pairs of elements arranged with the ends of the elements abutting one another, the compensator is closed, and with at least one pair of elements open so that the ends of the elements of that pair are spaced apart, an aperture is defined for the beam of radiation. 